Quantitative MRI using relaxometry in malignant gliomas detects contrast enhancement in peritumoral oedema.

ABSTRACT: Malignant gliomas are primary brain tumours with an infiltrative growth pattern, often with contrast enhancement on magnetic resonance imaging (MRI). However, it is well known that tumour infiltration extends beyond the visible contrast enhancement. The aim of this study was to investigate if there is contrast enhancement not detected visually in the peritumoral oedema of malignant gliomas by using relaxometry with synthetic MRI. 25 patients who had brain tumours with a radiological appearance of malignant glioma were prospectively included. A quantitative MR-sequence measuring longitudinal relaxation (R₁), transverse relaxation (R₂) and proton density (PD), was added to the standard MRI protocol before surgery. Five patients were excluded, and in 20 patients, synthet

SUBMITTER: Blystad I 

PROVIDER: S-EPMC7581520 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature