The genomic landscapes of individual melanocytes from human skin.

ABSTRACT: Every cell in the human body has a unique set of somatic mutations, but it remains difficult to comprehensively genotype an individual cell¹. Here we describe ways to overcome this obstacle in the context of normal human skin, thus offering a glimpse into the genomic landscapes of individual melanocytes from human skin. As expected, sun-shielded melanocytes had fewer mutations than sun-exposed melanocytes. However, melanocytes from chronically sun-exposed skin (for example, the face) had a lower mutation burden than melanocytes from intermittently sun-exposed skin (for example, the back). Melanocytes located adjacent to a skin cancer had higher mutation burdens than melanocytes from donors without skin cancer, implying that the mutation burden of normal skin can be used to measu

SUBMITTER: Tang J 

PROVIDER: S-EPMC7581540 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature