High-Density Lipoprotein Carries Markers That Track With Recovery From Stroke.

ABSTRACT:

Rationale

Prospective cohort studies question the value of HDL-C (high-density lipoprotein cholesterol) for stroke risk prediction.

Objective

Investigate the relationship between long-term functional recovery and HDL proteome and function.

Methods and results

Changes in HDL protein composition and function (cholesterol efflux capacity) in patients after acute ischemic stroke at 2 time points (24 hours, 35 patients; 96 hours, 20 patients) and in 35 control subjects were measured. The recovery from stroke was assessed by 3 months, the National Institutes of Health Stroke Scale and modified Rankin scale scores. When compared with control subject after adjustments for sex and HDL-C levels, 12 proteins some of which participate in acute phase response and platelet activati

SUBMITTER: Plubell DL 

PROVIDER: S-EPMC7581542 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature