Sulfamethoxazole drug stress upregulates antioxidant immunomodulatory metabolites in Escherichia coli.

ABSTRACT: Escherichia coli is an important model organism in microbiology and a prominent member of the human microbiota¹. Environmental isolates readily colonize the gastrointestinal tract of humans and other animals, and they can serve diverse probiotic, commensal and pathogenic roles in the host^2-4. Although certain strains have been associated with the severity of inflammatory bowel disease (IBD)^2,5, the diverse immunomodulatory phenotypes remain largely unknown at the molecular level. Here, we decode a previously unknown E. coli metabolic pathway that produces a family of hybrid pterin-phenylpyruvate conjugates, which we named the colipterins. The metabolites are upregulated by subinhibitory levels of the antifolate sulfamethoxazole, which is used to treat infec

SUBMITTER: Park HB 

PROVIDER: S-EPMC7581551 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature