Pure high-grade papillary urothelial bladder cancer: a luminal-like subgroup with potential for targeted therapy.

ABSTRACT:

Purpose

Non-invasive high-grade (HG) bladder cancer is a heterogeneous disease that is characterized insufficiently. First-line Bacillus Calmette-Guérin instillation fails in a substantial amount of cases and alternative bladder-preserving treatments are limited, underlining the need to promote a further molecular understanding of non-invasive HG lesions. Here, we characterized pure HG papillary urothelial bladder cancer (pure pTa HG), a potential subgroup of non-invasive HG bladder carcinomas, with regard to molecular subtype affiliation and potential for targeted therapy.

Methods

An immunohistochemistry panel comprising luminal (KRT20, ERBB2, ESR2, GATA3) and basal (KRT5/6, KRT14) markers as well as p53 and FGFR3 was used to analyze molecular subtype affiliations of 78 pur

SUBMITTER: Schnitzler T 

PROVIDER: S-EPMC7581583 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature