Antimicrobial metabolite profiling of Nigrospora sphaerica from Adiantum philippense L.

ABSTRACT:

Background

Endophyte bestows beneficial aspects to its inhabiting host, along with a contribution to diverse structural attributes with biological potential. In this regard, antimicrobial profiling of fungal endophytes from medicinal plant Adiantum philippense revealed bioactive Nigrospora sphaerica from the leaf segment. Chemical and biological profiling through TLC-bioautography and hyphenated spectroscopic techniques confirmed the presence of phomalactone as an antimicrobial metabolite.

Results

The chemical investigation of the broth extract by bioassay-guided fractionation confirmed phomalactone as a bioactive antimicrobial secondary metabolite. The antimicrobial activity of phomalactone was found to be highest against Escherichia coli by disc diffusion assay. The MIC wa

SUBMITTER: Ramesha KP 

PROVIDER: S-EPMC7581665 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature