TLR9-IL-2 axis exacerbates allergic asthma by preventing IL-17A hyperproduction.

ABSTRACT: Allergic asthma is one of most famous allergic diseases, which develops lung and airway inflammation. Recent studies have revealed the relationship between the pathology of allergic asthma and the increase of host-derived DNA in inflamed lung, but the role of the DNA-recognizing innate immune receptor for the inflammation is unknown well. Here we investigated the role of Toll-Like Receptor 9 in the pathogenesis of allergic asthma without synthesized CpG-ODNs. To examine that, we analyzed the pathology and immunology of house-dust-mite (HDM)-induced allergic asthma in Tlr9^-/- mice and TLR9-inhibitory-antibody-treated mice. In Tlr9^-/- mice, airway hyperresponsiveness (AHR) and the number of eosinophils decreased, and production of the Th2 cytokines IL-13, IL-5, and IL-4

SUBMITTER: Murakami Y 

PROVIDER: S-EPMC7581806 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature