Functional connectivity between resting-state networks reflects decline in executive function in Parkinson's disease: A longitudinal fMRI study.

ABSTRACT: Deficits in cognitive functioning are a common yet poorly understood symptom in Parkinson's disease (PD). Recent studies have highlighted the importance of (dynamic) interactions between resting-state networks for cognition, which remains understudied in PD. We investigated how altered (dynamic) functional interactions between brain networks relate to cognitive dysfunction in PD patients. In this fMRI study, 50 PD patients (mean age 65.5 years ± 6.27) on dopaminergic medication were studied cross-sectionally, and of this cohort 31 PD patients were studied longitudinally. MRI imaging and neuropsychological testing was performed at two time points, with a follow-up duration of approximately three years. Functional connectivity within and between seven resting-state networks was calculated (b

SUBMITTER: Boon LI 

PROVIDER: S-EPMC7581965 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature