Dementia risk in Parkinson's disease is associated with interhemispheric connectivity loss and determined by regional gene expression.

ABSTRACT: Parkinson's dementia is a common and devastating part of Parkinson's disease. Whilst timing and severity vary, dementia in Parkinson's is often preceded by visual dysfunction. White matter changes, representing axonal loss, occur early in the disease process. Clarifying which white matter connections are affected in Parkinson's with visual dysfunction and why specific connections are vulnerable will provide important mechanistic insights. Here, we use diffusion tractography in 100 Parkinson's patients (33 low visual performers) and 34 controls to identify patterns of connectivity loss in Parkinson's with visual dysfunction. We examine the relationship between regional transcription and connectivity loss, using the Allen Institute for Brain Science transcriptome atlas. We show that interhem

SUBMITTER: Zarkali A 

PROVIDER: S-EPMC7581968 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature