Nogo-B is a key mediator of hepatic ischemia and reperfusion injury.

ABSTRACT: Nogo-B is an endoplasmic reticulum-residential protein with distinctive functions in different diseases. However, it remains unclear the role of Nogo-B in liver sterile inflammatory injury. This study aims to elucidate the functions and mechanisms in liver ischemia and reperfusion injury (IRI). The Nogo-B expression and liver function were analyzed in biopsy/serum specimens from 36 patients undergoing ischemia-related hepatectomy and in a mouse model of liver IRI. Human specimens were harvested prior to ischemia and post-reperfusion. The Nogo-B knockout (Nogo-B^KO) and myeloid-specific Nogo-B knockout (Nogo-B^MKO) mice were used to analyze the function and mechanism of Nogo-B in a mouse model of liver IRI. In human specimens, the Nogo-B expression was positively correla

SUBMITTER: Rao J 

PROVIDER: S-EPMC7582106 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature