Long-term effect of intrathecal baclofen treatment on bone health and body composition after spinal cord injury: A case matched report.

ABSTRACT:

Background

Severe spasticity may negatively impact functionality and quality of life after spinal cord injury (SCI). Intrathecal baclofen treatment (IBT) is effectively used to manage severe spasticity and reduce comorbidities. However, long-term IBT may have a negative effect on bone mineral content (BMC), bone mineral density (BMD) and body composition (such as percentage fat mass and lean body mass). We demonstrated the negative effects of long-term IBT use in a single case compared with two non-IBT users.

Case summary

A 46-year old Caucasian male Veteran (case) with a 21 year history of complete tetraplegia (complete C6 SCI) was implanted with IBT for 20 years. The case was matched to two participants with different time since injuries [2 (match 1) and 13 (match 2) years

SUBMITTER: Ifon DE 

PROVIDER: S-EPMC7582109 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature