Incidence and Mortality of Second Primary Cancers in Danish Patients With Retinoblastoma, 1943-2013.

ABSTRACT:

Importance

In heritable retinoblastoma, there is a significantly increased risk of second primary cancers (SPCs). Improved knowledge about the incidence and influence of heritability and treatment is important during therapy for patients with retinoblastoma.

Objective

To assess the incidence of SPC in patients diagnosed with retinoblastoma in Denmark from 1943 to 2013 with a focus on heritability and the association of external radiotherapy with mortality.

Design, setting, and participants

In this retrospective cohort study, data were extracted from the Danish Ocular Oncology Group Database containing complete data on all patients diagnosed with retinoblastoma , and obtained from the Danish Cancer Registry, which includes information on all patients with cancer from 1

SUBMITTER: Gregersen PA 

PROVIDER: S-EPMC7582127 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature