Association of Uncommon, Noncoding Variants in the APOE Region With Risk of Alzheimer Disease in Adults of European Ancestry.

ABSTRACT:

Importance

The ε2 and ε4 alleles of the apolipoprotein E (APOE) gene are associated with Alzheimer disease (AD) risk. Although nearby genetic variants have also been shown to be associated with AD, including rs2075650 in the TOMM40 gene and rs4420638 near the APOC1 gene, it is unknown whether these associations are independent of the ε2 and ε4 alleles.

Objective

To assess whether variants near APOE are associated with AD independently of the ε2/ε3/ε4 genotype.

Design, setting, and participants

In this genetic association study of the Alzheimer's Disease Genetics Consortium imputed genotype at data, 14 415 variants near APOE (±500 kilobase) for 18 795 individuals with European ancestry were tested for association with AD using 4 logistic mixed models adjusting for sex,

SUBMITTER: Blue EE 

PROVIDER: S-EPMC7582128 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature