Chronic stress and antidepressant treatment alter purine metabolism and beta oxidation within mouse brain and serum.

ABSTRACT: Major depressive disorder (MDD) is a complex condition with unclear pathophysiology. Molecular disruptions within limbic brain regions and the periphery contribute to depression symptomatology and a more complete understanding the diversity of molecular changes that occur in these tissues may guide the development of more efficacious antidepressant treatments. Here, we utilized a mouse chronic social stress model for the study of MDD and performed metabolomic, lipidomic, and proteomic profiling on serum plus several brain regions (ventral hippocampus, nucleus accumbens, and medial prefrontal cortex) of susceptible, resilient, and unstressed control mice. To identify how commonly used tricyclic antidepressants impact the molecular composition in these tissues, we treated stress-exposed mice

SUBMITTER: Hamilton PJ 

PROVIDER: S-EPMC7582177 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature