Epigenetic alterations in skin homing CD4⁺CLA⁺ T cells of atopic dermatitis patients.

ABSTRACT: T cells expressing the cutaneous lymphocyte antigen (CLA) mediate pathogenic inflammation in atopic dermatitis (AD). The molecular alterations contributing to their dysregulation remain unclear. With the aim to elucidate putative altered pathways in AD we profiled DNA methylation levels and miRNA expression in sorted T cell populations (CD4⁺, CD4⁺CD45RA⁺ naïve, CD4⁺CLA⁺, and CD8⁺) from adult AD patients and healthy controls (HC). Skin homing CD4⁺CLA⁺ T cells from AD patients showed significant differences in DNA methylation in 40 genes compared to HC (p < 0.05). Reduced DNA methylation levels in the upstream region of the interleukin-13 gene (IL13) in CD4⁺CLA⁺ T cells from AD patie

SUBMITTER: Acevedo N 

PROVIDER: S-EPMC7582180 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature