Systemic Therapy and Sequencing Options in Advanced Hepatocellular Carcinoma: A Systematic Review and Network Meta-analysis.

ABSTRACT:

Importance

The treatment landscape for advanced hepatocellular carcinoma (HCC) has recently changed and become relatively confusing. Head-to-head comparisons between most of the available agents have not been performed and are less likely to be examined in a prospective fashion in the future. Therefore, a network meta-analysis (NMA) is helpful to compare different agents from across different trials.

Objective

To evaluate comparative effectiveness of different systemic treatments in advanced patients with HCC across lines of therapy.

Data sources

We searched various databases for abstracts and full-text articles published from database inception through March 2020.

Study selection

We included phase 3 trials evaluating different vascular endothelial growth facto

SUBMITTER: Sonbol MB 

PROVIDER: S-EPMC7582230 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature