SARs for the Antiparasitic Plant Metabolite Pulchrol. Part 2: B- and C-Ring Substituents.

ABSTRACT: Neglected tropical diseases affect most of the underprivileged populations in tropical countries. Among these are chagas and leishmaniasis, present mainly in South and Central America, Africa and East Asia. Current treatments are long and have severe adverse effects, therefore there is a strong need to develop alternatives. In this study, we base our research on the plant metabolite pulchrol, a natural benzochromene which has been shown to possess antiparasitic activity against Trypanosoma and Leishmania species. In a recent study, we investigated how changes in the benzyl alcohol functionality affected the antiparasitic activity, but the importance of B- and C-ring substituents is not understood. Fifteen derivatives of pulchrol with different substituents in positions 1, 2, 3, and 6 while

SUBMITTER: Terrazas P 

PROVIDER: S-EPMC7582507 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature