Higher genome mutation rates of Beijing lineage of Mycobacterium tuberculosis during human infection.

ABSTRACT: Mycobacterium tuberculosis (Mtb) strains of Beijing lineage have caused great concern because of their rapid emergence of drug resistance and worldwide spread. DNA mutation rates that reflect evolutional adaptation to host responses and the appearance of drug resistance have not been elucidated in human-infected Beijing strains. We tracked and obtained an original Mtb isolate of Beijing lineage from the 1999 tuberculosis outbreak in Japan, as well as five other isolates that spread in humans, and two isolates from the patient caused recurrence. Three isolates were from patients who developed TB within one year after infection (rapid-progressor, RP), and the other three isolates were from those who developed TB more than one year after infection (slow-progressor, SP). We sequenced genomes o

SUBMITTER: Hakamata M 

PROVIDER: S-EPMC7582865 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature