Patterning Chronic Active Demyelination in Slowly Expanding/Evolving White Matter MS Lesions.

ABSTRACT:

Background and purpose

Slowly expanding/evolving lesions measured by conventional T1-weighted/T2-weighted brain MR imaging may contribute to progressive disability accumulation in MS. We evaluated the longitudinal change in myelin and axonal tissue integrity in white matter slowly expanding/evolving lesions by means of the magnetization transfer ratio and DTI radial diffusivity.

Materials and methods

Slowly expanding/evolving lesions were detected within the Study to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of BIIB033 in Participants With Relapsing Forms of Multiple Sclerosis When Used Concurrently With Avonex (SYNERGY) Phase 2 clinical trial dataset (NCT01864148), comprising patients with relapsing-remitting and secondary-progressive MS (n = 29

SUBMITTER: Elliott C 

PROVIDER: S-EPMC7583098 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature