Gender Difference in the Association Between Metabolic Factors and Hepatocellular Carcinoma.

ABSTRACT:

Background

A gender difference in hepatocellular carcinoma (HCC) that men have higher incidence than women has long been noted and can be explained by the cross-talk between sex hormones and hepatitis B virus/hepatitis C virus (HBV/HCV). Whether metabolic factors yield similar sexual difference in non-HBV/HCV-HCC remains elusive.

Methods

There were 74 782 hepatitis B surface antigen (HBsAg)/antibody to hepatitis C virus (anti-HCV) negative residents who participated in the Keelung Community-Based Integrated Screening program and were followed in 2000-2007. Incident HCC was identified by linkage to the Taiwan Cancer Registry. Cox proportional hazards regression models were used to estimate the association between metabolic factors and HCC stratified by sex. All statistical te

SUBMITTER: Chen CL 

PROVIDER: S-EPMC7583157 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature