Serum IgE in the clinical features and disease outcomes of IgG4-related disease: a large retrospective cohort study.

ABSTRACT:

Objective

The aim of this study was to investigate the role of serum IgE levels in the clinical features and outcomes of IgG4-related disease (IgG4-RD).

Methods

We retrospectively enrolled 459 newly diagnosed IgG4-RD patients with serum IgE examined at baseline from 2012 to 2019 and compared the clinical features between group A (serum IgE level ≤ 60 KU/L) and group B (serum IgE level > 60 KU/L). Subsequently, 312 patients who had been followed up for ≥ 1 year were further selected to evaluate the correlation between serum IgE level and disease outcome.

Results

At baseline, the serum IgE level was positively correlated with the serum IgG4 level (r = 0.1779, P = 0.0001), eosinophil count (r = 0.3004, P < 0.0001), and serum IgG level (r = 0.2189, P < 0.0001) in IgG4-RD

SUBMITTER: Zhou J 

PROVIDER: S-EPMC7583198 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature