Compromised browning plasticity of primary subcutaneous adipocytes derived from overweight Chinese adults.

ABSTRACT:

Purpose

People with obesity have a compromised browning capacity of adipose tissue when faced with sympathetic stimuli. This study aimed to determine whether norepinephrine treatment can enhance the induction of precursor cells from human white adipose tissue to differentiate into adipocytes that express key markers of beige adipocytes, and if there is a difference in this capacity between normal weight and overweight individuals.

Methods

Stromal vascular cells derived from subcutaneous white adipose tissue of normal weight and overweight groups were induced to differentiation, with or without norepinephrine, into adipocytes. Oxygen consumption rate, lipolysis, the expression of uncoupling protein 1 and other thermogenic genes were compared between different adiposity and tr

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC7583200 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature