Ca_v2.3 channel function and Zn²⁺-induced modulation: potential mechanisms and (patho)physiological relevance.

ABSTRACT: Voltage-gated calcium channels (VGCCs) are critical for Ca²⁺ influx into all types of excitable cells, but their exact function is still poorly understood. Recent reconstruction of homology models for all human VGCCs at atomic resolution provides the opportunity for a structure-based discussion of VGCC function and novel insights into the mechanisms underlying Ca²⁺ selective flux through these channels. In the present review, we use these data as a basis to examine the structure, function, and Zn²⁺-induced modulation of Ca_v2.3 VGCCs, which mediate native R-type currents and belong to the most enigmatic members of the family. Their unique sensitivity to Zn²⁺ and the existence of multiple mechanisms of Zn²⁺ action strongly arg

SUBMITTER: Neumaier F 

PROVIDER: S-EPMC7583514 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature