Anticholinergic drugs and incident dementia, mild cognitive impairment and cognitive decline: a meta-analysis.

ABSTRACT:

Background

the long-term effect of the use of drugs with anticholinergic activity on cognitive function remains unclear.

Methods

we conducted a systematic review and meta-analysis of the relationship between anticholinergic drugs and risk of dementia, mild cognitive impairment (MCI) and cognitive decline in the older population. We identified studies published between January 2002 and April 2018 with ≥12 weeks follow-up between strongly anticholinergic drug exposure and the study outcome measurement. We pooled adjusted odds ratios (OR) for studies reporting any, and at least short-term (90+ days) or long-term (365+ days) anticholinergic use for dementia and MCI outcomes, and standardised mean differences (SMD) in global cognition test scores for cognitive decline outcomes. S

SUBMITTER: Pieper NT 

PROVIDER: S-EPMC7583519 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature