Low PTEN expression and overexpression of phosphorylated Akt^Ser473 and Akt^Thr308 are associated with poor overall survival in upper tract urothelial carcinoma.

ABSTRACT: The PI3K/Akt signaling pathway serves an essential role in various cellular processes, including cell growth, survival, cell motility, angiogenesis and cell metabolism. Loss of PTEN expression and hyperactivation of Akt can result in tumorigenesis. Previous studies observed expression of the Akt protein and absence of the PTEN protein in bladder cancer and non-small cell lung carcinoma tissues. The aim of the present study was to evaluate the expression status and prognostic value of PTEN and the PI3K/Akt signaling pathway in Taiwanese patients with upper tract urothelial carcinoma (UTUC). Archival formalin-fixed, paraffin-embedded (FFPE) tissues from 65 UTUC cases were stained via immunohistochemistry for PTEN, phosphorylated (p)Akt serine (Ser)⁴⁷³ and pAkt threonine (Thr)

SUBMITTER: Weng WH 

PROVIDER: S-EPMC7583738 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature