Autophagy Dynamics and Modulation in a Rat Model of Renal Ischemia-Reperfusion Injury.

ABSTRACT: Renal ischemia-reperfusion (IR) injury leading to cell death is a major cause of acute kidney injury, contributing to morbidity and mortality. Autophagy counteracts cell death by removing damaged macromolecules and organelles, making it an interesting anchor point for treatment strategies. However, autophagy is also suggested to enhance cell death when the ischemic burden is too strong. To investigate whether the role of autophagy depends on the severity of ischemic stress, we analyzed the dynamics of autophagy and apoptosis in an IR rat model with mild (45 min) or severe (60 min) renal ischemia. Following mild IR, renal injury was associated with reduced autophagy, enhanced mammalian target of rapamycin (mTOR) activity, and apoptosis. Severe IR, on the other hand, was associated with a hi

SUBMITTER: Decuypere JP 

PROVIDER: S-EPMC7583807 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature