Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies.

ABSTRACT: Gene expression dictates fundamental cellular processes and its de-regulation leads to pathological conditions. A key contributor to the fine-tuning of gene expression is Dicer, an RNA-binding protein (RBPs) that forms complexes and affects transcription by acting at the post-transcriptional level via the targeting of mRNAs by Dicer-produced small non-coding RNAs. This review aims to present the contribution of Dicer protein in a wide spectrum of human pathological conditions, including cancer, neurological, autoimmune, reproductive and cardiovascular diseases, as well as viral infections. Germline mutations of Dicer have been linked to Dicer1 syndrome, a rare genetic disorder that predisposes to the development of both benign and malignant tumors, but the exact correlation of Dicer protei

SUBMITTER: Theotoki EI 

PROVIDER: S-EPMC7583940 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature