Identification of differentially expressed genes in ulcerative colitis and verification in a colitis mouse model by bioinformatics analyses.

ABSTRACT:

Background

Ulcerative colitis (UC) is an inflammatory bowel disease that is difficult to diagnose and treat. To date, the degree of inflammation in patients with UC has mainly been determined by measuring the levels of nonspecific indicators, such as C-reactive protein and the erythrocyte sedimentation rate, but these indicators have an unsatisfactory specificity. In this study, we performed bioinformatics analysis using data from the National Center for Biotechnology Information-Gene Expression Omnibus (NCBI-GEO) databases and verified the selected core genes in a mouse model of dextran sulfate sodium (DSS)-induced colitis.

Aim

To identify UC-related differentially expressed genes (DEGs) using a bioinformatics analysis and verify them in vivo and to identify novel bi

SUBMITTER: Shi L 

PROVIDER: S-EPMC7584051 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature