Evidence of Long-range nerve pathways connecting and coordinating activity in secondary lymph organs.

ABSTRACT:

Background

Peripheral nerve reflexes enable organ systems to maintain long-term physiological homeostasis while responding to rapidly changing environmental conditions. Electrical nerve stimulation is commonly used to activate these reflexes and modulate organ function, giving rise to an emerging class of therapeutics called bioelectronic medicines. Dogma maintains that immune cell migration to and from organs is mediated by inflammatory signals (i.e. cytokines or pathogen associated signaling molecules). However, nerve reflexes that regulate immune function have only recently been elucidated, and stimulation of these reflexes for therapeutic effect has not been fully investigated.

Methods

We utilized both electrical and ultrasound-based nerve stimulation to activate nerve p

SUBMITTER: Cotero V 

PROVIDER: S-EPMC7584093 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature