Wolbachia and Sirtuin-4 interaction is associated with alterations in host glucose metabolism and bacterial titer.

ABSTRACT: Wolbachia is an intracellular bacterial symbiont of arthropods notorious for inducing many reproductive manipulations that foster its dissemination. Wolbachia affects many aspects of host biology, including metabolism, longevity and physiology, being described as a nutrient provisioning or metabolic parasite, depending on the host-microbe association. Sirtuins (SIRTs) are a family of NAD+-dependent post-translational regulatory enzymes known to affect many of the same processes altered by Wolbachia, including aging and metabolism, among others. Despite a clear overlap in control of host-derived pathways and physiology, no work has demonstrated a link between these two regulators. We used genetically tractable Drosophila melanogaster to explore the role of sirtuins in shaping signaling path

SUBMITTER: Carneiro Dutra HL 

PROVIDER: S-EPMC7584242 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature