Metal-Dependent Cytotoxic and Kinesin Spindle Protein Inhibitory Activity of Ru, Os, Rh, and Ir Half-Sandwich Complexes of Ispinesib-Derived Ligands.

ABSTRACT: Ispinesib is a potent inhibitor of kinesin spindle protein (KSP), which has been identified as a promising target for antimitotic anticancer drugs. Herein, we report the synthesis of half-sandwich complexes of Ru, Os, Rh, and Ir bearing the ispinesib-derived N,N-bidentate ligands (R)- and (S)-2-(1-amino-2-methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-one and studies on their chemical and biological properties. Using the enantiomerically pure (R)- and (S)-forms of the ligand, depending on the organometallic moiety, either the S_M,R or R_M,S diastereomers, respectively, were observed in the molecular structures of the Ru- and Os(cym) (cym = η⁶-p-cymene) compounds, whereas the R

SUBMITTER: Lomzik M 

PROVIDER: S-EPMC7584371 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature