Potently neutralizing and protective human antibodies against SARS-CoV-2.

ABSTRACT: The ongoing pandemic of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major threat to global health¹ and the medical countermeasures available so far are limited^2,3. Moreover, we currently lack a thorough understanding of the mechanisms of humoral immunity to SARS-CoV-2⁴. Here we analyse a large panel of human monoclonal antibodies that target the spike (S) glycoprotein⁵, and identify several that exhibit potent neutralizing activity and fully block the receptor-binding domain of the S protein (S_RBD) from interacting with human angiotensin-converting enzyme 2 (ACE2). Using competition-binding, structural and functional studies, we show that the monoclonal anti

SUBMITTER: Zost SJ 

PROVIDER: S-EPMC7584396 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature