Impaired spermatogenesis in COVID-19 patients.

ABSTRACT:

Background

The current study aimed to determine the impact of SARS-CoV-2 infection on male fertility.

Methods

This is a single-center, hospital-based observational study that included autopsied testicular and epididymal specimens of deceased COVID-19 male patients (n=6) and recruited recovering COVID-19 inpatients (n=23) with an equal number of age-matched controls, respectively. We performed histopathological examinations on testicular and epididymal specimens, and also performed TUNEL assay and immunohistochemistry. Whereas, we investigated the semen specimen for sperm parameters and immune factors.

Findings

Autopsied testicular and epididymal specimens of COVID-19 showed the presence of interstitial edema, congestion, red blood cell exudation in teste

SUBMITTER: Li H 

PROVIDER: S-EPMC7584442 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature