Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology.

ABSTRACT:

Aims

Treatment of arrhythmias evoked by hypothermia/rewarming remains challenging, and the underlying mechanisms are unclear. This in vitro experimental study assessed cardiac electrophysiology in isolated rabbit hearts at temperatures occurring in therapeutic and accidental hypothermia.

Methods and results

Detailed ECG, surface electrogram, and panoramic optical mapping were performed in isolated rabbit hearts cooled to moderate (31°C) and severe (17°C) hypothermia. Ventricular activation was unchanged at 31°C while action potential duration (APD) was significantly prolonged (176.9 ± 4.2 ms vs. 241.0 ± 2.9 ms, P < 0.05), as was ventricular repolarization. At 17°C, there were proportionally similar delays in both activation and repolarization. These changes were reflected in

SUBMITTER: Dietrichs ES 

PROVIDER: S-EPMC7584464 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature