Genetic Association of Epilepsy and Anti-Epileptic Drugs Treatment in Jordanian Patients.

ABSTRACT:

Purpose

The aim of this study was to investigate the possible effects of single-nucleotide polymorphisms (SNPs) within SLC1A1, SLC6A1, FAM131B, GPLD1, F2, GABRG2, GABRA1, and CACNG5 genes on response to anti-epileptic drugs (AEDs) and the genetic predisposition of epilepsy in Jordanian patients.

Patients and methods

A total of 299 healthy individuals and 296 pediatric patients from the Jordanian population were recruited. Blood samples are collected, and genotyping was performed using a custom platform array analysis.

Results

The SLC1A1 rs10815018 and FAM131B rs4236482 polymorphisms found to be associated with epilepsy susceptibility. Moreover, SLC1A1 rs10815018 and GPLD1 rs1126617 polymorphisms were associated with generalized epilepsy (GE), while FAM131B rs4236482 i

SUBMITTER: Al-Eitan LN 

PROVIDER: S-EPMC7584512 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature