Ontology highlight
ABSTRACT:
SUBMITTER: Poulet M
PROVIDER: S-EPMC7584612 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Communications biology 20201023 1
Protein tyrosine phosphatases are essential modulators of angiogenesis and have been identified as novel therapeutic targets in cancer and anti-angiogenesis. The roles of atypical Phosphatase of Regenerative Liver (PRL) phosphatases in this context remain poorly understood. Here, we investigate the biological function of PRL phosphatases in developmental angiogenesis in the postnatal mouse retina and in cell culture. We show that endothelial cells in the retina express PRL-2 encoded by the Ptp4a ...[more]