An analytical approach to determine the optimal duration of continuous glucose monitoring data required to reliably estimate time in hypoglycemia.

ABSTRACT: Diabetes is a chronic metabolic disease that causes blood glucose (BG) concentration to make dangerous excursions outside its physiological range. Measuring the fraction of time spent by BG outside this range, and, specifically, the time-below-range (TBR), is a clinically common way to quantify the effectiveness of therapies. TBR is estimated from data recorded by continuous glucose monitoring (CGM) sensors, but the duration of CGM recording guaranteeing a reliable indicator is under debate in the literature. Here we framed the problem as random variable estimation problem and studied the convergence of the estimator, deriving a formula that links the TBR estimation error variance with the CGM recording length. Validation is performed on CGM data of 148 subjects with type-1-diabetes. First

SUBMITTER: Camerlingo N 

PROVIDER: S-EPMC7584616 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature