Placental MRI: Development of an MRI compatible ex vivo system for whole placenta dual perfusion.

ABSTRACT:

Purpose

Placental dysfunction plays a key role in diseases that affect the fetus in utero and after birth. Aiming to develop a platform for validating in vivo placental MRI and investigations into placental physiology, we designed and built a prototype MRI-compatible perfusion chamber with an integrated MRI receive coil for high SNR ex vivo placental imaging.

Principal results

After optimizing placenta vascular clearing and perfusion protocols, we performed contrast enhanced MR angiography and MR relaxometry on eight carefully selected placentas while they were perfused via the umbilical arteries (UAs). Additionally, two of these placentas underwent maternal perfusion via the intervillous space (IVS). Despite striving for homogenous perfusion across the whole placenta, imagi

SUBMITTER: Stout JN 

PROVIDER: S-EPMC7584726 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature