Proteomic Signatures of Heart Failure in Relation to Left Ventricular Ejection Fraction.

ABSTRACT:

Background

There is a growing recognition of the inherent limitations of the use of the left ventricular ejection fraction (LVEF) to accurately phenotype patients with heart failure (HF).

Objectives

The authors sought to identify unique proteomic signatures for patients with HF with reduced ejection fraction (HFrEF), HF with a midrange LVEF (HFmrEF), and HF with preserved ejection fraction (HFpEF), as well as to identify molecular differences between patients with ischemic and nonischemic HF.

Methods

We used high-content aptamer-based proteomics technology (SOMAscan) to interrogate the blood proteome of age- and sex-matched patients with HF within different LVEF groups.

Results

Within the Washington University Heart Failure Registry, we identified age/sex-match

SUBMITTER: Adamo L 

PROVIDER: S-EPMC7584807 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature