Age-related gene expression alterations by SARS-CoV-2 infection contribute to poor prognosis in elderly.

ABSTRACT: The ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide and with notable heterogeneity in its clinical presentation. Probability of contracting this highly contagious infection is similar across age groups but disease severity and fatality among aged patients with or without comorbidities are reportedly higher. Previous studies suggest that age associated transcriptional changes in lung and immune system results in a proinflammatory state and increased susceptibility to infectious lung diseases. Similarly, SARS-CoV-2 infection could augment ageing-related gene expression alterations resulting in severe outcomes in elderly patients. To identify genes that can potentially increase covid-19 disease severity in agein

SUBMITTER: Bhattacharyya U 

PROVIDER: S-EPMC7584866 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature