Chronicling changes in the somatosensory neurons after peripheral nerve injury.

ABSTRACT: Current drug discovery efforts focus on identifying lead compounds acting on a molecular target associated with an established pathological state. Concerted molecular changes that occur in specific cell types during disease progression have generally not been identified. Here, we used constellation pharmacology to investigate rat dorsal root ganglion neurons using two models of peripheral nerve injury: chronic constriction injury (CCI) and spinal nerve ligation (SNL). In these well-established models of neuropathic pain, we show that the onset of chronic pain is accompanied by a dramatic, previously unreported increase in the number of bradykinin-responsive neurons, with larger increases observed after SNL relative to CCI. To define the neurons with altered expression, we charted the tempo

SUBMITTER: Raghuraman S 

PROVIDER: S-EPMC7584894 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature