Posttranscriptional regulation of human endogenous retroviruses by RNA-binding motif protein 4, RBM4.

ABSTRACT: The human genome encodes for over 1,500 RNA-binding proteins (RBPs), which coordinate regulatory events on RNA transcripts. Most studies of RBPs have concentrated on their action on host protein-encoding mRNAs, which constitute a minority of the transcriptome. A widely neglected subset of our transcriptome derives from integrated retroviral elements, termed endogenous retroviruses (ERVs), that comprise ∼8% of the human genome. Some ERVs have been shown to be transcribed under physiological and pathological conditions, suggesting that sophisticated regulatory mechanisms to coordinate and prevent their ectopic expression exist. However, it is unknown how broadly RBPs and ERV transcripts directly interact to provide a posttranscriptional layer of regulation. Here, we implemented a computation

SUBMITTER: Foroushani AK 

PROVIDER: S-EPMC7585035 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature