Staphylococcus aureus Preferentially Liberates Inorganic Phosphate from Organophosphates in Environments where This Nutrient Is Limiting.

ABSTRACT: Phosphate is an essential nutrient that Staphylococcus aureus and other pathogens must acquire from the host during infection. While inorganic monophosphate (P_i) is the preferred source of this nutrient, bacteria can also obtain it from phosphate-containing organic molecules. The P_i-responsive regulator PhoPR is necessary for S. aureus to cause infection, suggesting that P_i is not freely available during infection and that this nutrient must be obtained from other sources. However, the organophosphates from which S. aureus can obtain phosphate are unknown. We evaluated the ability of 58 phosphorus-containing molecules to serve as phosphate sources for S. aureus Forty-six of these compounds, including phosphorylated amino acids, s

SUBMITTER: Kelliher JL 

PROVIDER: S-EPMC7585055 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature