The Evolutionary Conservation of Escherichia coli Drug Efflux Pumps Supports Physiological Functions.

ABSTRACT: Bacteria harness an impressive repertoire of resistance mechanisms to evade the inhibitory action of antibiotics. One such mechanism involves efflux pump-mediated extrusion of drugs from the bacterial cell, which significantly contributes to multidrug resistance. Intriguingly, most drug efflux pumps are chromosomally encoded components of the intrinsic antibiotic resistome. In addition, in terms of xenobiotic detoxification, bacterial efflux systems often exhibit significant levels of functional redundancy. Efflux pumps are also considered to be highly conserved; however, the extent of conservation in many bacterial species has not been reported and the majority of genes that encode efflux pumps appear to be dispensable for growth. These observations, in combination with an increasing body

SUBMITTER: Teelucksingh T 

PROVIDER: S-EPMC7585057 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature