Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis.

ABSTRACT: Metformin is a widely used drug for type 2 diabetes that is considered to have potential anti-aging effects. However, the beneficial effects of metformin in middle-aged normoglycemic mice are less explored. Here, we report that metformin treated by tail vein injection improved cognitive function of aged mice better than oral administration, which seem to show a dose-dependent manner. Correspondingly, long-term oral administration of metformin was associated with significant disability rates. Further, metformin restored cerebral blood flow and brain vascular density and promoted neurogenic potential of the subependymal zone/subventricular zone both in vivo and in vitro. RNA-Seq and q-PCR results indicated that metformin could enhance relative mRNA glycolysis expression in bloo

SUBMITTER: Zhu X 

PROVIDER: S-EPMC7585073 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature