Transcriptomic analysis reveals gender differences in gene expression profiling of the hypothalamus of rhesus macaque with aging.

ABSTRACT: Due to the current delay in childbearing, the importance of elucidating the underlying mechanisms for reproductive aging has increased. Human fertility is considered to be controlled by hormones secreted by the hypothalamic-pituitary-gonadal axis. To clarify the changes in hypothalamic gene expression with increasing age, we performed paired-end strand-specific total RNA sequencing for the hypothalamus tissues of rhesus. We found that hypothalamic gene expression in females was more susceptible to aging than that in males, and reproductive aging in females and males might have different regulatory mechanisms. Intriguingly, the expression of most of the hormones secreted by hypothalamus showed no significant difference among the macaques grouped by age and gender. Moreover, the age-related

SUBMITTER: Fan Y 

PROVIDER: S-EPMC7585077 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature