A newly defined risk signature, consisting of three m⁶A RNA methylation regulators, predicts the prognosis of ovarian cancer.

ABSTRACT: N6-methyladenosine (m⁶A) RNA methylation, involved in cancer initiation and progression, is dynamically regulated by the m⁶A RNA methylation regulators. However, the expression of m⁶A RNA methylation regulators in ovarian cancer and their correlation with prognosis remain elusive. Here, we demonstrated that the 18 central m⁶A RNA methylation regulators were expressed differently between ovarian cancer (OC) and normal tissues. By applying consensus clustering, all ovarian cancer patient cases can be divided into three subgroups (cluster1/2/3) based on overall expression levels of all 18 m⁶A RNA methylation regulators. We systematically analyzed the prognostic value of transcription levels of 18 m⁶A RNA methylation regulators

SUBMITTER: Fan L 

PROVIDER: S-EPMC7585096 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature