Association of serum growth differentiation factor-15 with eGFR and hemoglobin in healthy older females.

ABSTRACT:

Purpose

Anemia and sarcopenia associated with renal dysfunction caused by cytokine imbalance can contribute to decreased quality of life for older individuals. Growth differentiation factor-15 (GDF-15) is associated with renal dysfunction, although whether it is related to anemia or sarcopenia is unclear. In this study we examined the association of GDF-15 with renal function, hemoglobin and sarcopenia in healthy community-dwelling older females in Japan.

Methods

A total of 66 healthy older community-dwelling females (age: 75.8 ± 6.2 years) were enrolled for this study. Skeletal muscle mass index was determined by bioelectrical impedance analysis. Hand-grip strength and walking speed were also assessed. Serum GDF-15 concentration was determined by enzyme-linked immunosorbent

SUBMITTER: Yazawa H 

PROVIDER: S-EPMC7585132 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature