Effect of anticoagulant adjustment on prothrombin time test using two different PT reagents in patients with elevated hematocrit.

ABSTRACT: The recommendations for adjustment of citrate volume in sample tubes with high hematocrit (Ht) are based on indirect studies of underfilled tubes or artificially constructed Ht values. The aim of this study was to evaluate the effect of citrate volume adjustment in sample tubes from patients with hematocrit >55% using two different prothrombin time (PT) tests.

Methods

Paired citrate-adjusted and unadjusted blood specimens were obtained from 181 patients from the pulmonary hypertension ambulatory with high Ht values and on warfarin therapy. The samples were tested using recombinant human tissue factor (RTF) and reagents extracted from rabbit brain (HS Plus). The results are expressed as the international normalized ratio (INR). The correlation and percent change (% change) between sa

SUBMITTER: Silva VM 

PROVIDER: S-EPMC7585133 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature