Hypertension is associated with reduced hippocampal connectivity and impaired memory.

ABSTRACT:

Background

The objective was a large-scale analysis of the relation between hypertension, memory problems, and brain function.

Methods

The study design was to measure the association between a history of hypertension, and the functional connectivity between 94 brain regions, and prospective and numeric memory, in 19,507 participants from the UK Biobank, with cross-validation in 1,002 participants in the Human Connectome Project, and 13,441 individuals in the second release of the UK Biobank. A history of hypertension was measured by whether individuals were admitted to hospital for the treatment of hypertension, with the control group admissions for other reasons.

Findings

A history of hypertension was associated with reduced functional connectivity of the hippocampus

SUBMITTER: Feng R 

PROVIDER: S-EPMC7585137 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature